Protein Details: Gamma-aminobutyric acid receptor subunit alpha-5
Protein ID
ICDB_Pro_0479
Protein Name
Gamma-aminobutyric acid receptor subunit alpha-5
Gene Name
GABRA5
Organism
Homo sapiens (Human)
Length
462 amino acids
AlphaFoldDB
AF-P31644-F1-model_v4.pdb
Function
Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA);a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels;also named GABA(A) receptors (GABAAR);consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA;GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. GABAARs containing alpha-5/GABRA5 subunits are mainly extrasynaptic and contribute to the tonic GABAergic inhibition in the hippocampus (By similarity). Extrasynaptic alpha-5-containing GABAARs in CA1 pyramidal neurons play a role in learning and memory processes (By similarity).
Sequence
Ligand Binding
Binding Site
BINDING 101; /ligand="4-aminobutanoate": "ligand shared with the neighboring beta subunit GABRB3"; BINDING 164; /ligand="4-aminobutanoate": "ligand shared with the neighboring beta subunit GABRB3"
Disease
Developmental And Epileptic Encephalopathy and Non-Specific Early-Onset Epileptic Encephalopathy
Location
DOI ID
10.1042/bst020018s; 10.1093/hmg/2.2.183; 10.1038/ng1285; 10.1101/gr.2596504; 10.1006/geno.1997.4770; 10.1073/pnas.0307231101; 10.1002/pmic.200600410; 10.1038/s41422-018-0077-8; 10.1093/braiwy171; 10.1093/braiwz123
RefSeq
NP_000801.1; NP_001158509.1; XP_005268315.1; XP_006720522.1